Cyclothiazomycin

The cyclothiazomycins are a group of natural products produced by various Streptomyces species of bacteria. These compounds are ribosomally synthesized and post-translationally modified peptides (RiPPs) and can be further classified as thiopeptides. The overall structure of the cyclothiazomycins comprises a macrocyclic bicyclic peptide containing several thiazoles and thiazolines. The cyclothiazomycins are reported to have multiple inhibitory effects ranging from decreasing blood pressure to interfering with RNA transcription; they also exhibit some antibiotic activity.
History
Cylothiazomycin A was first isolated from Streptomyces sp. NR0516 in 1991. The structure of cyclothiazomycin A was solved via NMR spectroscopy and chemical degradation. Previously, a peptide compound 5102-II had been isolated in 1982 from Streptomyces hygroscopicus 10-22. The discovery of the genes responsible for the biosynthesis of cyclothiazomycin in 2010...