Telenzepine

Telenzepine is a selective M1 antimuscarinic used in the treatment of peptic ulcers. Telenzepine is atropisomeric, in other words the molecule has a stereogenic C–N-axis; in neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active as the (–)-isomer at muscarinic receptors in the rat cerebal cortex.
See also

Pirenzepine

References
External links

Telenzepine is at least 25 times more potent than pirenzepine--a dose response and comparative secretory study in man, Gut., 1987 July; 28(7): 888–895


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